How do you make Peyton Manning struggle?
Wear a San Diego Chargers uniform.
Lousy joke aside, it’s no secret that arguably the greatest quarterback in NFL history doesn’t fare well against the Chargers.

Peyton Manning is a MNF stud…but historically at times a dud against San Diego. (courtesy Mike Orbeck)
Entering Monday night’s Week 6 finale, Manning ranks in the top five in passing yards (1,499) and passer rating (101.0), but his career line against San Diego – all as an Indianapolis Colt – isn’t as impressive:
- 12 touchdowns
- 16 interceptions
- 72.5 passer rating
Manning’s is 4-5 against San Diego during his career, including two playoff losses. In fact, Manning is 1-5 in his last six career meetings with the Chargers, 1-4 against Norv Turner coached Chargers teams.
- 1998: W, 17-12
- 1999: W, 27-19
- 2004: W, 34-31 (OT)
- 2005: L, 17-26
- 2007: L, 21-23 (Infamous 6 INT game)
- 2007 Playoffs: L, 24-28
- 2008: W, 23-20
- 2008 Playoffs: L, 17-23
- 2010: L, 36-14
Manning has thrown only three interceptions this season, all in the same quarter of the same game. Since that Week 2 Monday night game in Atlanta, Manning has gone 15 quarters minus a pick. Manning played uncharacteristically sloppy football in his last Monday night appearance. With an all-time MNF record of 11-4, chances are Manning won’t drop two straight…
Even if the Chargers have historically given No. 18 fits.
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